Overview
Semax is studied in research involving neuropeptide signaling and neurotrophic factor expression. Researchers investigate how peptide sequences related to adrenocorticotropic hormone (ACTH) fragments interact with signaling pathways in neural tissue.
Technical Research Details
Semax is a synthetic peptide based on a fragment of the ACTH(4-10) sequence, modified with a C-terminal Pro-Gly-Pro extension intended to increase resistance to enzymatic degradation. It has been the subject of laboratory research involving neuropeptide signaling, neurotrophic factor expression, oxidative-stress responses, and neuroinflammatory pathways in preclinical models.
This product is supplied exclusively as a research material. It is not intended for diagnostic, therapeutic, dietary, cosmetic, veterinary, or human use.
Research Notes
Semax belongs to a group of short peptides derived from the non-hormonal region of ACTH. Because the ACTH(4-10) fragment lacks the portion of the parent molecule associated with steroidogenic activity, research on Semax has focused on signaling in neural tissue rather than endocrine output.
Preclinical literature has examined Semax in the context of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, modulation of the dopaminergic and serotonergic systems, and cellular responses to oxidative and ischemic stress in animal and in vitro models. The added Pro-Gly-Pro sequence is frequently cited as a structural feature that slows peptidase cleavage relative to the unmodified fragment.
Because this research area is still developing relative to more extensively characterized peptides, researchers should treat mechanistic findings as an active and evolving area of study rather than settled conclusions.
Documentation
Supplier-provided laboratory documentation is available for this product. This report was not independently commissioned by Alpha Tides PNW — see our Certificates of Analysis page for the full document and source notes.
Storage Notes
Maintaining compound integrity requires proper storage before and after reconstitution:
- Before reconstitution: Store the lyophilized vial at -20°C, away from light and moisture. Bring to room temperature before opening to prevent condensation.
- After reconstitution: Refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
- Recommended solvent: Bacteriostatic water for most research protocols.
For complete handling procedures, see the Research Compound Storage Guide and Reconstitution Protocol.
Related Research
- How to Store Research Compounds Properly — Storage protocols for lyophilized research compounds
- How to Reconstitute Lyophilized Compounds — Step-by-step reconstitution guide
- Research Hub — Full library of compound guides and research references
Semax is intended strictly for laboratory research by qualified professionals. Not FDA approved. Not for human or animal use. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws.
Laboratory Testing
Certificate available
